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Research timelines vary by compound and model, so there is no fixed figure

Sakaguchi and Furusawa 2006)

Biochemistry 51, 52855292

Inhibition of mTORC1 promotes autophagy, which facilitates the clearance of unwanted cytoplasmic proteins and reduces the accumulation of toxic metabolites, thereby mitigating cellular stress and extending lifespan

It ensures that cells produce energy efficiently while protecting them from the biological rust caused by inflammation

Then what I noticed is that people were coming back between three and four weeks saying, "Hey, I don't feel as good as I did after I did that loading dose." We started doing a once-a-month maintenance dose, and that is what we still recommend to do today