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The plant hormone jasmonate (JA) plays a crucial signaling role in eliciting nicotine biosynthesis in response to damage, activating transcriptional regulators that coordinate the expression of downstream metabolic and transport genes

In addition to the addictive qualities of nicotine, the physical habit of smoking can make quitting hard to manage

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With a 25-cent tax increase, 1.5% fewer people aged 18 to 24 smoked a reduction more than three times as big as the next closest age group, those aged 25-44

The risk increases with the duration and intensity of tobacco use

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