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Tobacco contains more than 4000 chemical compounds, 60 of which are known carcinogens

For core disease outcomes such as relapse rates, MRI activity, and disability, RCTs of individual nutrients (e.g., biotin, polyunsaturated fatty acids) or antioxidants (e.g., lipoic acid, Ginkgo biloba) have largely shown no significant benefit [51, 101, 112, 158]

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Public health researchers acknowledge this gap: the tax works best when neighboring states have comparable rates, and worst when dramatic tax differentials exist across short distances