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In addition to lungs, nicotine has profound systemic effects on many organs such as kidneys, heart, liver, and gastrointestinal tract, mediated through damage to epithelial, endothelial, and fibroblast cells [84]

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[27] Nicotine can also be delivered via other tobacco products such as chewing tobacco, snus, pipe tobacco, hookah, all of which can produce nicotine dependence