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The Government argues that the new regulations also seek to close legal loopholes left outside the current law by the rapid spread of new nicotine products

However, there was no reduction in risk for those who reduced smoking, even among those who reduced by more than 50%

There seems to be a spectrum of nicotine metabolism time that varies by level of female sex hormones, with metabolism times progressing from slower in men, to intermediate in women not on oral contraceptives, to faster in women taking oral contraceptives, Benowitz and colleagues observed