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Early studies on Gly-His-Lys (GHK), first discovered in human plasma in the 1970s, demonstrated their ability to modulate gene expression, stimulate collagen synthesis, and accelerate wound healing, sparking broad interest in these bioactive molecules [23]
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Beyond the effects of the microglia, human and animal studies have shown that endotoxin-induced inflammation can also increase the neural responses in the anterior cingulate cortex and prefrontal regions, further impacting the processing of social and emotional information [218]
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