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After adjusting for age, sex, CPD, creatinine, and BMI, African Americans had significantly higher urinary amounts of TNE than Whites, and Whites had significantly higher TNE levels than Japanese Americans, as described in more detail in the next section

17 Furthermore, in a model of inhalational tolerance, prolonged cigarette smoke exposure of mice significantly delayed the establishment of tolerance induced by repeated harmless antigen challenges

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The PN intervention concluded at the week 12 assessment

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