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A tobacco product manufacturer, distributor, or retailer would be required to submit a plan for the random and equal display and distribution of the required warnings on packages and the quarterly rotation in advertisements for approval by FDA

Although the true mechanism remains unclear, we posit that arterial stiffness explains the blood pressure subtraction difference from baseline between the hypertensive and nonhypertensive groups 26

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Overall nicotine uptake increased with increasing nicotine content and was comparable to that of cigarettes for Velo ONPs with higher nicotine levels