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After the sequencing of the human genome, in the early 2000s, the Broad Institute launched in 2010 the Connectivity Map, where numerous compounds were analyzed to find out what was their influence on the expression of genes

Hum Pathol 35:10007, PMID: 15297967 Pai HV, Starke DW, Lesnefsky EJ, Hoppel CL, Mieyal JJ (2007) What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria

Some parameters including duration of cercarial suspension on ice (30 to 60 min), centrifugation time (5 to 10 min), centrifugal force (800 to 1000 rpm ) and steps during purification (3 to 5) were modified to enhance conversion rates of cercariae into schistosomula

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American Pharmaceutical Association

10.1007/s00415-017-8550-8 228