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Crack and heroin users represent an ageing population as fewer young people use Class A drugs, though there remain 460 people with the most serious problems outside treatment

In addition, treatment with the endoplasmic reticulum (ER) stress activators tunicamycin and thapsigargin has been shown to induce Parkin-dependent mitophagy to alleviate neuronal apoptosis, thereby protecting against ischemic brain injury [123] ( Fig

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