HSP70 has been involved in the regulation steps of skeletal muscle plasticity [30, 31, 99, 100], apoptosis, and cell death, affecting protein refolding processes, signalling for ubiquitin degradation, and translocation of proteins [101]
First, although HG exposure is widely recognized in the literature as a common in vitro model to mimic diabetes-induced cellular damage, it does not fully replicate the complexity of the DR
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Two patients did not complete the treatment period due to side effects, and five more did not complete the posttreatment measurements
in 2018 (PMID: 29155147) in Biochemical Pharmacology
doi: 10.1038/s41586-019-1705-2, 30