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However, since a larger fraction of the total drug in the body is now free, the steady-state concentration of free drug increases significantly, posing a major risk of toxicity

Mild redness or a small bump at the site is normal and goes away within an hour

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The dose increases at weeks five and nine bring the most challenging side effect periods

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Blunted or impeded therapeutic response to vitamin B 12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency