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It is the mirror image of insulin - insulin puts energy away, glucagon takes it back out

Paiva I et al 2022 Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Limited Human Reports A small number of human publications exist, but their scale and design do not establish general safety or effectiveness

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The observed transcriptomic signatures of vulnerable brain regions pointed towards the dopamine biosynthetic process and oxygen transport that were highly expressed in brain regions related to the preclinical stages of PD

Cho M, Kim S, Chun S