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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections

These include modulations in gene expression, stimulation of the endocannabinoid system, and action on the central nervous system

For Semaglutide injections to be most effective, avoid foods high in fat, sugar, and empty calories

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Below is a general compounded semaglutide dosage progression, but individual needs may vary based on tolerance, weight loss goals, and healthcare provider recommendations