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This is in line with the antigen-specificity of the response promoted by peptide immunotherapy, and resulted in the suppression by the pCons-induced T regs of the proliferation of CD4 + CD25 - T effectors cells and reduced production of proinflammatory cytokines

However, it is critical to emphasize that all current evidence comes from in-vitro and animal studies human clinical data is not yet available

MOTS-c also regulates nuclear gene expression beyond AMPK, affecting glucose metabolism and oxidative capacity at the transcriptional level

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