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Tobacco-related illnesses kill 400,000 Americans every year

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Biochem Biophys Res Commun 509:514520 Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS (2006) Epidermal growth factor receptor (EGFR) signaling in cancer

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A: Smoking is the primary cause of smokers cough, but it can also be triggered by exposure to secondhand smoke or underlying respiratory conditions