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Ferroptosis in immunostimulation and immunosuppression

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Vitamin B2 (riboflavin) plays a crucial role in redox reactions, serving as a precursor for coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)

Further, the crystal structure of NLRP3 revealed a disulfide bond between conserved cysteine residues in the inflammasome active site, suggesting redox-sensitive activity (Zhou et al., 2011