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It contributes to energy production by supporting the metabolism of fatty acids and the synthesis of acetyl-coenzyme A, the central substrate for energy production that also helps maintain homeostasis between catabolic and anabolic reactions

When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

Cells were analysed by flow cytometry using a BD LSR II instrument

Li X, Liu C, Mao Z, Xiao M, Wang L, Qi S, et al

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