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This work was funded in part through a grant from the National Institute on Alcohol Abuse and Alcoholism to the Prevention Research Center at Penn State.

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Analysis of Variance (ANOVA) analyses were performed on log CFU and Inverse Simpson indices with R version 3.5.1

Content validityestablishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO good research practices task force reportPart 1eliciting concepts for a new PRO instrument

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