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for human genetic variation

Milk thistle (Silybum marianum) for the therapy of liver disease. American Journal of Gastroenterology 1998, 93(2): 139-143

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This is accomplished through the upregulation of key SMAD proteins SMAD2, SMAD3, and SMAD5, serving as intracellular effectors of the TGF- signaling pathway, which is crucial for follicular development, oogenesis, and GCs function