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"Hackman and wife died of natural causes several days apart, officials say"

Nicotine harms brain development, which continues until about age 25, the Centers for Disease Control and Prevention says, and the American Lung Association says long-term use can lead to permanent damage to lung tissue, stroke and heart disease

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(1998) found increased activation in the insula, frontal lobes, and amygdala after cumulative intravenous nicotine administration in cigarette smokers [17]

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