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Lactate-induced lactylation and cardiometabolic diseases: from epigenetic regulation to therapeutics

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JCI Insight 7 , e155899 (2022)

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Excessive amounts of built-up toxins in your body, over an extended amount of time, can cause irreversible damage and even death

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It activates genes linked to collagen production, wound healing, and immune support while suppressing those involved in inflammation and oxidative stress

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PGC-1 upregulates the expression of GLUT4 in skeletal muscle [103,104,105], inhibits pro-inflammatory cytokine production [106], and is a co-activator of the retinoic X receptor (RXR) [83,85,107]

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After one hour, coverslips were washed in blocking buffer, and further labeled with Alexa Fluor 488-conjugated secondary antibodies (Invitrogen, Carlsbad, CA) for one hour at RT as above

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