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Clonidine (Catapres): This is a blood-pressure medication used for nicotine dependence as a last resort, due to the side effects of drowsiness

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It is lightweight and easier to carry, but it does not provide the same level of protection as hard packs

tested six tobacco flavored e-liquids and one menthol flavored e-liquid in mice through whole-body inhalation exposure and observed increased OX/ROS reactivity along with oxidative stress in the presence of flavoring agents in the absence of nicotine

Tobacco addiction develops because the brain becomes less and less sensitive to nicotine, and a greater amount of nicotine is required to obtain the same effect

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