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All treatment-emergent adverse reactions are included except those listed in Table 3, those listed in other safety-related sections of the prescribing information, those subsumed under COSTART terms that are either overly general or excessively specific so as to be uninformative, those not reasonably associated with the use of the drug, and those that were not serious and occurred in fewer than 2 subjects

In fact, tear instability and ocular surface damage have been linked to second-hand smoke

( Why synthetic pot could be the future of pain relief .) The method of consumption may also play a role