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The article from Prasse et al suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]. Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease

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February 24, 2026

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"This temporary moratorium wouldn't be necessary if the federal government had done its job," says Herrera

The use of smokeless tobacco can lead to chronic irritation and inflammation in the airways [103], contributing to the development of respiratory conditions such as large airway inflammation or bronchitis