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A spontaneous report cannot prove causation, but it is relevant to safety surveillance

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Peptide analogs and biomaterial based strategies such as self-assembling peptide hydrogels and biomimetic compounds remain in earlier developmental phases, with preclinical research indicating capacity for disc regeneration, stem cell preservation, and improved disc structure and mechanics, though clinical application awaits validation and long term safety assessment [4041]

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Proper injection technique minimizes tissue irritation from the acidic B1 component