The amount of p-BSQ present in the smoke solution was calculated from the peak area, taking 100 ng of p-BSQ corresponding to an arbitrary area of 1,90,000 obtained from a standard curve
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However, sustained activation of TRPA1 and persistent inflammatory neuronal stimulation may exacerbate chronic respiratory conditions including asthma [114]
These important parameters of a cMRTP can be assessed through measuring product use satisfaction, craving, nicotine exposure and daily consumption in clinical studies conducted in an ambulatory setting [44]