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Previously eaten for its medicinal properties, opium smoking became widespread in China and the West during the 19th century

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See no other possibility

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Arterioscler Thromb Vasc Biol 41(2):839853 Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL et al (2019) Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice