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Mitochondria are specialized membrane-bound organelles that play key roles in iron metabolism in that they synthesize heme, assemble iron-sulfur proteins, and are involved in the cellular iron regulation

It recycles vitamins C and E, neutralizes free radicals, binds heavy metals, and supports liver detox

Taken together, ferroptosis is a PCD mechanism intricately associated with iron metabolism, lipid peroxidation, and antioxidant systems (Figure 4A)

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Cytoplasmic tyramine also activates intracellular trace amineassociated receptor 1 (TAAR1), resulting the phosphorylation of NET, inducing a conformational change of the transporter that results in a reversal of its transport direction