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248 On the other hand, one meta-analysis of 5 trials that compared web-based interventions with active comparison conditions (such as face-to-face or telephone counseling) found that the pooled effect estimate was not significant (RR = 0.92, 95% CI = 0.781.09, N = 3,806, I 2 = 0%)

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The severity of withdrawal symptoms varies between individuals and is predictive of relapse rates, with increased severity associated with higher chances of returning to smoking

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