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Chronic Constipation and Diarrhea Slowed-down peristalsis due to the nicotine effect on smooth muscle cells found within walls of the intestines may lead to prolonged transit time, hence chronic constipation while increased activity can cause rapid passing of food leading to watery stools thus diarrhea

The rats that had been exposed to nicotine had 'impaired autoresuscitation' and had a 'significant delay' in recovering normal breathing and heart rate

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Abbott Chapter 1: Context of Practice: Myths, Realities, and Quagmires Related to Alcohol, Tobacco, and Other Drugs Ann A