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nAChRs might be present in the neuronal terminals that innervate the cardiac muscle, although it has been described that only glutamatergic neurons and peripheral crustacean cardioactive peptide neurons reach the Drosophila heart (Dulcis and Levine, 2005)

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Additionally, devices may have different health impacts when used to vape cannabis or other drugs besides nicotine, which requires further investigation

The risk may be even higher for menthol products