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doi: 10.3389/fphys.2021.638491

Application of DON and its prodrugs in tumor therapy DON (6diazo5oxolnorleucine), a Gln antagonist developed for the treatment of solid tumors, was originally isolated from the fermentation broth of Streptomyces in the 1950s, which competitively binds to the active site of glutamate in vivo and then forms a covalent adduct that irreversibly inhibit the enzymatic active

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doi: 10.1016/j.freeradbiomed.2020.10.307 47 DixonSJStockwellBR

While he was raised in a very small farming community, he had the good fortune of living just 30 minutes from the world-famous Mayo Clinic in Rochester, Minnesota and was intrigued by the hospital environment from an early age

When daily oxidative stress outpaces what the body can produce, glutathione stores run lower than they should