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Nicotine receptors are widely distributed across the brain, the central nervous system (CNS - particularly in the spinal cord), peripheral nervous system, and other tissues (adrenal medulla, lungs, immune cells, skin, intestinal lining and other tissues)

As blood vessels age, they naturally lose flexibility and become more vulnerable to damage

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However, non-compliance is common as the global transport of waste continues to expand

A more serious side effect to consider is seizures, as bupropion is said to reduce the seizure threshold