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Patients with a prior history of serious gastrointestinal adverse events and other known risk factors that are associated with peptic ulcer disease ( alcoholism, smoking) are at increased risk

9.6 GSH-depletion mediated cancer therapy Reducing intracellular GSH levels enhances reactive oxygen species (ROS)-based therapies by weakening the cells antioxidant protection mechanisms Fig

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Many would develop scurvy, a life-threatening vitamin C deficiency