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Gradual dose escalation over 4-8 weeks allows assessment of individual response and tolerance

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Some peptides may distribute into different tissues throughout the body, including fat tissue

We will compare the mean Bayley-III scores (scores on the cognitive, language and motor subscale scores, with the language scale analysed both separately for receptive and expressive language and as a composite measure, and the motor scale analysed both separately for fine and gross motor development and as a composite measure) between the vitamin B 12 group and the placebo group

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Vitamin B12 has a good safety profile, but some important considerations include rare hypersensitivity reactions (including anaphylaxis) with injections, potential hypokalaemia during early treatment of severe deficiency, and possible cutaneous reactions