The compound has been extensively studied for its effects on angiogenesis, tendon and ligament repair, gastrointestinal mucosal protection, and modulation of the nitric oxide (NO) pathway
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In theory, combining them could offer complementary benefits
A report from the Framingham Offspring Study of 2,999 adults found the following average daily B12 intakes, including fortified foods and supplements (Tucker, 2000): Age 26-49: 8.9 g Age 50-64: 8.7 g Age 65-83: 8.5 g A 2015-2016 National Health and Nutrition Examination Survey of over 4,500 adults 60 years and older found the following average daily B12 intakes (USDA NHANES, 2019): Male non-supplement users (68% of men): 4.5 g Male supplement users: 5.3 g from food plus 326 g from supplements Female non-supplement users (63% of women): 3.6 g Female supplement users: 3.8 g from food plus 520 g from supplements European Food Safety Authoritys Recommendations In 2015, the EFSA released recommendations for B12 intake across Europe
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2007 Copper tripeptide complexes increase VEGF production while decreasing TGF-1 secretion by dermal fibroblasts
