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Insulin-like growth factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review

It helps in optimising mitochondrial function, which is crucial for maintaining energy at the cellular level

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Glutathione is required for many critical cellular processes and plays a particularly important role in the maintenance and regulation of the thiol-redox status of the cell [73]

However, in some other tissues, IGF-I expression appears to be regulated by tissue specific trophic factors, as for example in uterus, where estrogens (and not GH) stimulate IGF-I expression[26], while follicle stimulating hormone is a major IGF-I regulator in ovary[27]

Ajay Kale: Supervision, critical revision of the manuscript for important intellectual content, and overall guidance throughout the study