Gallagher et al [138] found no significant variation in DNA adduct levels in sperm from heavy smokers (20 cigarettes/d), light smokers ( A of NAT2 can therefore be used as a novel genetic marker for susceptibility to idiopathic male infertility, but the risk is potentiated by exposure to various environmental oxidants, including cigarette smoke
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Gallic acid, 2.0 N Folin-Ciocalteus phenol reagent (FCR), 2,4,6,-Tris(2-pyridyl)-s-triazine (TPTZ), 2,2-Diphenyl-1-picrylhydrazyl (DPPH), and ()-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% (Trolox) were obtained from Sigma-Aldrich (Castle Hill NSW, Australia)
Assuming this mechanism is responsible for the strand bias in SBS_I, this is indicative of adduct formation on adenine bases
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