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[86] Nicotine is a parasympathomimetic stimulant [89] that binds to and activates nicotinic acetylcholine receptors in the brain, [90] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [91] and several neuropeptides, including proopiomelanocortin-derived -MSH and adrenocorticotropic hormone

These are perfect for smokers that are wanting to Vape, but not to consume any more nicotine

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While not risk-free, all of these products are a better alternative to smokingbut the best choice is to quit tobacco and nicotine use altogethe r .

10.1165/rcmb.2004-0363OC 89 MaideenN

n = 684), 22.6% transitioned to no tobacco use, 60.1% continued cigarette use, 11.4% dual use, and 5.9% e-cigarette mono-use