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Patients on Metformin : Patients with type 2 diabetes treated with metformin may experience reduced vitamin B12 absorption

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Combined NNMT inhibition and lean-diet substitution improves adiposity and body-composition endpoints in DIO mice

26 A review of 17 clinical studies of various trial designs, including pro- and retrospective, concluded that B12, particularly subcutaneously injected mB12 [methyl-B12], improves metabolic abnormalities in ASD along with clinical symptoms

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PMID 17284744