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The fact that mutant ATXN3 aggregates are also found in axons and that components that ensure protein homeostasis are in close proximity led to the hypothesis that the aggregation process occurring within axons may affect mechanisms of axonal transport of mRNA, proteins, and organelles and thereby contribute to a wider neuronal dysfunction in SCA3 [30]

Blood examination showed an elevated estradiol level as high as 3482 pg/ml

This condition can cause chronic pain, stiffness, and reduced mobility of the elbow joint when left untreated

Notch/RBPJ signaling also promotes the expression of the bHLH gene, Hes5, which (together with Sox2) marks quiescent and actively dividing early progenitor populations in the hippocampus [70]

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