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Design of prodrugs with reactive oxygen species as activators and their application in tumor therapy

A phase III clinical trial was then designed to further examine the effect of high-dose coenzyme Q 10 (1,200-2,400 mg/day) and vitamin E (1,200 IU/day) supplementation on both motor and non-motor symptoms associated with Parkinsons disease

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Synaptic co-release of thiamine and ACh, with thiamine facilitating the neurotransmission through its non-coenzyme action, is known from the early works of Minz and von Muralt on neuromuscular junctions (143, 165167)

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