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Soluble oligomers of amyloid-beta cause changes in redox state, DNA methylation, and gene transcription by inhibiting EAAT3 mediated cysteine uptake

In adipose tissue, inhibition of NNMT suppresses de novo lipogenesis, normalizes fat content, and improves insulin sensitivity 2-3

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422 Some studies also showed that HER2 heterogeneity correlated with worse clinical outcomes, 423 and HER2 intra-tumoral heterogeneity could be another potential factor for the resistance to anti-HER2 therapy

Clinical trials to date, such as the REDEFINE program, demonstrate dose-dependent weight loss of up to approximately 10% at 12 weeks and improvements in glycemic control markers