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Smoking tends to push SHBG higher, so more of your hormone stays trapped and less remains free and active which explains why many smokers feel classic Low T symptoms even when a basic lab report shows a normal total testosterone level

Future research should use large prospective cohorts, objective biomarkers of smoking and vaping exposure, and standardised laboratory-based glycaemic outcomes

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The effect of rate of antidepressant tapering on the incidence of discontinuation symptoms: a randomised study