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Genetic knockout (KO) of Rac1 in excitatory neurons in mice resulted in decreased spine and synapse numbers accompanied by increased postsynaptic density (PSD) ( in vitro through constitutively active Rac1 in cultured hippocampal slices leads to increased spine density but reduced spine size (Nakayama et al., 2000

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Abstract Dopamine (DA) neurotransmission is critical in the neurobiology of reward and aversion, but its contribution to the aversive state of opioid withdrawal remains unknown in humans

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Glutathione is a tripeptide composed of three amino acids: cysteine, glycine, and glutamic acid