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The combination is used in clinical practice under physician supervision based on mechanistic reasoning, preclinical evidence, and clinical experience

doi: 10.1007/s00467-004-1713-8 75 OhY

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The webserver takes a two-dimensional chemical structure as an input and reports the possible toxicity profile of the chemical for 33 models with confidence scores, and an overall toxicity radar chart along with three most similar compounds with known acute toxicity 37

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Preclinical research has examined its role in promoting angiogenesis, reducing oxidative stress in intestinal tissue, and interacting with the nitric oxide system to modulate gut blood flow