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Additionally, the gut microbiota is essential for the existence and functionality of intestinal CD8+ T cells, as well as their capacity to modulate other immune cell populations, including natural killer cells, plasmacytoid dendritic cells, and marginal zone B cells (9294)

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Polymorphisms in genes encoding drug-metabolizing enzymes, such as CYP450, can alter the way drugs are processed in the liver, making genetic screening a potential tool for identifying individuals at higher risk for DILI [92]

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