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Conclusions Overall, the results of the present review indicate a potential increase in the risk of therapeutic failure for smokers assuming drugs whose metabolism may be influenced by smoking, and represent a further strong motivation to encourage interventions to stop smoking cigarettes

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Recommend to anyone who wants to give up smoking but likes the feel of a cigarette in their hands

The working group also used GRADE to determine the certainty of the evidence and strength of the recommendation (Box 1).21 Appendices 47 (available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content) provide the evidence-to-decision frameworks the task force used to develop recommendations

"If you're elderly, you can get more strokes and heart attacks