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In summary, in 2025, the Group incurred 1,575 million (2024: 9,154 million) of adjusting items within profit from operations: Years ended 31 December 2025 2024 m m (a) Restructuring and integration costs 66 (b) Amortisation and impairment of trademarks and similar intangibles 1,584 2,279 (b) Impairment of goodwill 277 39 (c) Impairment on held-for-sale assets and associated costs 235 (c) (Credit)/charges in respect of an excise assessment in Romania (15) 449 (c) Credit in respect of settlement of historical litigation in relation to the Fox River (132) (c) Charges in respect of DOJ and OFAC investigations 4 (c) Impairment charges in respect of the Group's operations in Cuba 74 (c) Impairment of other fixed assets 75 (c) Loss of a distribution facility in Ukraine 39 (c) Pension liability management (buy-out) 28 (c) Other adjusting items (including Engle) 66 157 (d) (Credit)/charges in relation to Canada Approved Plans (708) 6,203 Charges in connection with disposal of an associate 3 6 Total adjusting items included in profit from operations 1,575 9,154 (a) Restructuring and integration costs To further support our transformation and underpin investment initiatives to drive long-term sustainable profit and cash flow growth, we have started a structured time-bound programme (referred to as Fit2Win) to review processes and ways of working which will generate efficiencies and facilitate faster, more agile and effective decision-making

The lack of association of adeno with pipe and cigar smoking is also evident in the RRs for pipes only (0.50, 0.23-1.10, n = 4) and for cigars only (0.55, 0.11-2.88, n = 3)

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